RIFM fragrance ingredient safety assessment, 3,7-dimethyl-1,6-nonadien-3-ol, CAS Registry Number 10339-55-6

Area of Science:

• Toxicology
• Chemical Safety Assessment

Background:

• The safety of chemical substances is crucial for consumer and environmental protection.
• Existing data and read-across approaches are vital for comprehensive safety evaluations.

Purpose of the Study:

• To evaluate the safety of the material for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety.
• To support the current use conditions of the material based on scientific evidence.

Main Methods:

• Utilized read-across methodology using linalool (CAS # 78-70-6) and nerolidol (CAS # 7212-44-4) as analogs.
• Assessed genotoxicity, skin sensitization, local respiratory toxicity, repeated dose toxicity, and developmental/reproductive toxicity.
• Evaluated phototoxicity/photoallergenicity using UV spectra and environmental safety per the RIFM Framework.

Main Results:

• Linalool analog data indicated no genotoxicity or skin sensitization potential.
• Margins of Exposure (MOE) > 100 were achieved for local respiratory toxicity (linalool analog) and repeated dose, developmental/reproductive toxicity (nerolidol analog).
• Phototoxicity/photoallergenicity and environmental safety assessments were completed based on UV spectra and the RIFM Framework, respectively.

Conclusions:

• The material is not genotoxic and does not pose a risk for skin sensitization.
• Adequate safety margins were demonstrated for local respiratory, repeated dose, and developmental/reproductive toxicity.
• The material's use under current conditions is supported by the comprehensive safety evaluation.