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Prostaglandin derivatives inhibit the growth of malarial parasites in mice
S T Ohnishi1, N Ohnishi, Y Oda
1Membrane Research Institute, University City Science Center, Philadelphia, PA.
Cell Biochemistry and Function
|April 1, 1989
Abstract:
New prostaglandin oligomeric derivatives, termed MR-256 and MR-356, were found to inhibit the growth of murine malarial parasites, P. chabaudi and P. vinckei, within red blood cells in vivo. When mice were infected with P. chabaudi, both MR-256 and MR-356 suppressed the growth of parasites, but MR-356 had a greater inhibitory effect than MR-256. With P. vinckei, MR-356 also inhibited the growth of parasites, and improved the survival rate. The effect of MR-256 was much less. A possible inhibitory mechanism of action of these drugs is discussed.