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Updated: Mar 14, 2026
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Fractionated Gamma Knife surgery for giant pituitary adenomas
Kai Zhao1, Xiaomin Liu1, Dong Liu1
1Gamma Knife Center, Department of Neurosurgery, The 2nd Hospital of Tianjin Medical University, Tianjin, China.
Objective:
To analyze the feasibility and effectiveness of fractionated Gamma Knife surgery (FGKS) for giant pituitary adenomas.
Methods:
From June 2005 to May 2016, 14 patients with giant pituitary adenomas were treated with FGKS, and 10 patients (71%) completed follow-up evaluation. All patients had undergone surgical resection at least once prior to FGKS. The median-volume of the adenomas was 17.6cm3(range 4.9-61cm3).
Results:
The median follow-up period was 31.5 months (range 6-58 months). The size of the tumors decreased in 6 patients and remained stable in 4 patients. The visual acuity improved in 1 patient. None of the patients suffered from vision deterioration caused by FGKS.
Conclusion:
FGKS is an effective treatment modality for giant pituitary adenomas in selected patients.
