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Updated: Mar 14, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
Published on: May 30, 2025
[Lixisenatide in patients with type 2 diabetes and obesity: Beyond glycaemic control]
M Mar Roca-Rodríguez1, María Teresa Muros de Fuentes2, Gonzalo Piédrola-Maroto2
1UGC de Endocrinología y Nutrición, Hospital Universitario Puerta del Mar, Cádiz, España.
Aim:
To evaluate tolerance to lixisenatide and its effects on weight and metabolic control in type2 diabetes and obese patients.
Design:
Prospective study.
Setting:
Endocrinology clinics in Almeria, Granada and Malaga.
Participants:
Patients with type2 diabetes and obesity.
Interventions:
Response and tolerance to lixisenatide treatment.
Main Measurements:
Clinical and analytical data of the subjects were evaluated at baseline and after treatment.
Results:
The study included 104 patients (51% women) with type2 diabetes and obesity (Almeria 18.3%; Granada 40.4%; Malaga 41.3%). The mean age was 58.4±10.5years, and the mean duration of diabetes was 11.2±6.7years. The patients were re-evaluated at 3.8±1.6months after treatment with lixisenatide. Significant improvements were found in weight (P<.001), body mass index (P<.001), waist circumference (P=.002), systolic blood pressure (P<.001), diastolic blood pressure (P=.001), fasting glucose (P<.001), HbA1c (P=.022), Total cholesterol (P<.001), LDL-cholesterol (P=.046), triglycerides (P=.020), hypertension drugs (P<.001), and lipids drugs (P<.001). No changes were observed in levels of amylase related to lixisenatide treatment, and 7.9% of patients did not tolerate it.
Conclusions:
Lixisenatide achieved significant improvements in anthropometric parameters, glycaemic control (fasting glucose and HbA1c), blood pressure and lipids. It was safe and well tolerated in most patients. In addition, there was a significant increase in the use of antihypertensive and lipid-lowering therapy.
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