Five-Year PROSE Treatment for Aniridic Keratopathy

Area of Science:

• Ophthalmology
• Regenerative Medicine

Background:

• Aniridic keratopathy is a severe complication of aniridia, often leading to vision loss.
• It results from limbal stem cell deficiency, making conventional treatments insufficient.

Purpose of the Study:

• To report the management of aniridic keratopathy using scleral lenses.
• To evaluate the efficacy of scleral lens treatment in a patient with severe aniridic keratopathy.

Main Methods:

• A case study of a 30-year-old woman with bilateral aniridic keratopathy.
• Treatment involved conventional therapies followed by scleral lens (Prosthetic Replacement of the Ocular Surface Ecosystem; PROSE) therapy.
• Long-term monitoring of ocular surface health and visual acuity.

Main Results:

• Scleral lens treatment led to rapid healing of epithelial defects and improved visual acuity.
• The patient maintained corneal transparency and visual function for years with scleral lens use.
• Both eyes showed positive outcomes with scleral lens intervention.

Conclusions:

• Long-term scleral lens treatment is a viable option for aniridic keratopathy.
• Early scleral lens intervention may prevent corneal scarring and preserve vision.