Related Experiment Video
Updated: Mar 14, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Effect of serum YKL-40 on coronary collateral development and SYNTAX score in stable coronary artery disease
Mehmet Kadri Akboga1, Ridvan Yalcin2, Asife Sahinarslan2
1Turkiye Yuksek Ihtisas Training and Research Hospital, Department of Cardiology, Ankara, Turkey.
Insights
Serum YKL-40 levels are linked to poor coronary collateral development and higher SYNTAX scores in stable coronary artery disease patients. This suggests YKL-40 may predict these outcomes.
Area of Science:
- Cardiology
- Biomarkers
- Inflammation
Background:
- YKL-40 is an inflammatory biomarker associated with cardiovascular events.
- Its role in coronary collateral development and disease severity requires further investigation.
Purpose of the Study:
- To investigate the association between serum YKL-40 levels and coronary collateral development.
- To explore the relationship between serum YKL-40 and SYNTAX score in patients with stable coronary artery disease.
Main Methods:
- 165 patients with significant coronary artery stenosis were prospectively enrolled.
- Coronary collateral degree was assessed using the Rentrop-Cohen classification.
- Patients were categorized into good (grade 2-3) and poor (grade 0-1) collateral groups and by low (≤22) and high (>22) SYNTAX scores.
Main Results:
- Serum YKL-40 and hs-CRP levels were lower in the good collateral group.
- YKL-40 positively correlated with SYNTAX score (r=0.486, p<0.001) and hs-CRP (r=0.340, p<0.001).
- YKL-40 was an independent predictor of good collateral development (OR: 0.928; 95% CI: 0.917-0.940; p<0.001).
Conclusions:
- Increased serum YKL-40 levels are associated with poor coronary collateral development.
- Elevated YKL-40 is linked to higher SYNTAX scores.
- YKL-40 may serve as a predictor for both collateralization status and coronary artery disease complexity.
Objective:
Many studies have revealed a role of YKL-40 as a new inflammatory biomarker in angiogenesis, inflammation, atherosclerosis and cardiovascular events. Thus, the aim of this study was to investigate the association of serum YKL-40 level with coronary collateral development and SYNTAX score in patients with stable coronary artery disease.
Methods:
A total of 165 patients who had ≥90% stenosis in at least one major coronary artery were prospectively enrolled in the study. Collateral degree was graded according to Rentrop-Cohen classification. Patients with grade 2 or 3 collateral degree were included in good collateral group and patients with grade 0 or 1 collateral degree were included in poor collateral group. The patients were also classified according to SYNTAX criteria, those with low (≤22) and those with high (>22) SYNTAX score.
Results:
Serum YKL-40 and hs-CRP levels were significantly lower in good collateral group. Furthermore, YKL-40 level showed significant positive correlations with SYNTAX score (r=0.486, p<0.001) and hs-CRP level (r=0.340, p<0.001). In multivariate regression analysis, serum YKL-40 (odds ratio: 0.928; 95% confidence interval: 0.917-0.940; p<0.001), duration of ischemic symptom and total occlusion were independent predictors of good collateral development. In ROC curve analysis, a YKL-40 value cut-off point of ≥168.5 predicted the high SYNTAX score with a sensitivity of 81.0% and specificity of 72.4%.
Conclusions:
Increased serum YKL-40 level was related with poor collateral development and high SYNTAX score. According to these findings YKL-40 can be used as a predictor of good collateral development and high SYNTAX score.
More Related Videos
Related Concept Videos
01:26Coronary Artery Disease II: Pathophysiology
01:26Coronary Artery Disease IV: Preventive Measures
01:27Coronary Artery Disease V: Interprofessional Care
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:28Acute Coronary Syndrome IV: Interprofessional Care