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Immunotherapy for Gastroesophageal Cancer

Emily F Goode1, Elizabeth C Smyth2

  • 1The Royal Marsden Hospital, NHS Foundation Trust, London SW3 6JJ, UK. Emily.goode@rmh.nhs.uk.

Journal of Clinical Medicine
|September 27, 2016
PubMed

Insights

Immunotherapy offers new hope for advanced gastroesophageal cancers. Early trials of checkpoint inhibitors like anti-PD-1 show promise, warranting further investigation for these difficult-to-treat cancers.

Area of Science:

  • Oncology
  • Immunology
  • Gastroenterology

Background:

  • Advanced esophageal and stomach cancers have poor survival rates, causing over a million global deaths annually.
  • Current treatments like chemotherapy and targeted therapies offer limited survival benefits without long-term cure.
  • Immunotherapy, particularly checkpoint inhibitors, has transformed outcomes in other cancer types.

Purpose of the Study:

  • To review the early efficacy data of immunotherapy in gastroesophageal cancer patients.
  • To identify potential biomarkers associated with treatment response.
  • To discuss future directions for immunotherapy in this patient population.

Main Methods:

  • Review of early clinical trial data for anti-Programmed Cell Death Protein-1 (anti-PD-1), anti-PD-L1, and anti-Cytotoxic T-lymphocyte associated protein-4 (anti-CTLA4) agents.
  • Assessment of biomarkers predictive of response to immunotherapy.
  • Synthesis of current evidence and future outlook.

Main Results:

  • Early immunotherapy trials in gastroesophageal cancer demonstrate potential efficacy.
  • Specific biomarkers are being investigated for their role in predicting response.
  • Further research is needed to optimize treatment strategies.

Conclusions:

  • Immunotherapy represents a promising new avenue for treating advanced gastroesophageal cancers.
  • Understanding response biomarkers is crucial for personalized treatment approaches.
  • Continued investigation into novel immunotherapy strategies is essential for improving patient outcomes.
Keywords:
anti-PD-1anti-PD-L1checkpoint inhibitoresophageal cancergastric cancerimmunotherapyipilimumabnivolumabpembrolizumab

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