RIFM fragrance ingredient safety assessment, linalyl benzoate, CAS Registry Number 126-64-7

Area of Science:

• Fragrance chemistry and toxicology
• Risk assessment of cosmetic ingredients

Background:

• The safety of fragrance ingredients is crucial for consumer products.
• Existing data supports the current use of this material.
• Comprehensive toxicological evaluation is required for regulatory compliance.

Purpose of the Study:

• To evaluate the safety of the material for its intended use.
• To assess genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety.
• To ensure the material meets safety standards based on scientific data.

Main Methods:

• Utilized read-across approaches with established analogs like linalyl phenylacetate, linalyl cinnamate, linalool, dehydrolinalool, benzoic acid, and sodium benzoate.
• Assessed genotoxicity, skin sensitization, repeated dose toxicity, developmental and reproductive toxicity, and local respiratory toxicity.
• Evaluated phototoxicity/photoallergenicity using UV spectra and environmental safety following the RIFM Framework.

Main Results:

• The material was found to be non-genotoxic.
• No skin sensitization potential was identified.
• Margin of Exposure (MOE) values greater than 100 were obtained for repeated dose, developmental and reproductive, and local respiratory toxicity endpoints.
• Phototoxicity/photoallergenicity and environmental safety were assessed and deemed acceptable.

Conclusions:

• The material is safe for use under current conditions.
• The comprehensive toxicological profile supports its continued application in consumer products.
• The use of read-across analogs provided robust safety data for risk assessment.