Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new paradigm for pain?

Bennet Davis1, Todd W Vanderah2

  • 1The Integrative Pain Center of Arizona, Tucson, AZ, USA.

The Journal of Family Practice
|September 28, 2016
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multilevel Work Environment Factors and Occupational Well-Being Among APRNs Delivering Opioid Use Disorder Treatment: A Multistate Cross-Sectional Study.

Substance use : research and treatment·2026
Same author

Barettin Suppresses Pancreatic Ductal Adenocarcinoma Proliferation via Topoisomerase IIα Inhibition.

Marine drugs·2026
Same author

Temporal multi-omic exploration of the ventral tegmental area in chronic pain and passive coping behaviors.

iScience·2026
Same author

Postoperative multimodal pain management: a narrative review of current practices, clinical and educational gaps, and future directions.

Frontiers in anesthesiology·2026
Same author

Evaluation of Dronabinol to Decrease Opioid Use for Cancer-Induced Bone Pain.

The oncologist·2026
Same author

Barettin, a Nonopioid, Nonhallucinogenic Marine Natural Product with Antihyperalgesic Properties Mediated by 5HT2A Inverse Agonism.

Journal of natural products·2026
Same journal

Does taking BP medicine at night (vs morning) result in fewer cardiovascular events?

The Journal of family practice·2023
Same journal

Preventing RSV in children and adults: A vaccine update.

The Journal of family practice·2023
Same journal

Essential oils: How safe? How effective?

The Journal of family practice·2023
Same journal

51-year-old woman • History of Graves disease • General fatigue, palpitations, and hand tremors • Dx?

The Journal of family practice·2023
Same journal

Renewing the dream.

The Journal of family practice·2023
Same journal

55-year-old woman • Myalgias and progressive symmetrical proximal weakness • History of unilateral renal agenesis, type 2 diabetes, and hyperlipidemia • Dx?

The Journal of family practice·2023
See all related articles

A novel perspective on pain without apparent injury may change how we treat conditions such as fibromyalgia. This approach focuses on the brain's role in pain perception, offering new therapeutic avenues.

Area of Science:

  • Neuroscience
  • Pain Medicine
  • Psychology

Background:

  • Chronic pain conditions like fibromyalgia often lack clear pathophysiological explanations.
  • Current treatment paradigms may be insufficient for pain states without identifiable tissue damage or injury.

Purpose of the Study:

  • To propose a new conceptual framework for understanding pain.
  • To explore how this framework could impact the management of conditions characterized by pain in the absence of injury, such as fibromyalgia.

Main Methods:

  • Conceptual analysis of pain mechanisms.
  • Review of existing literature on centralized pain and fibromyalgia.
  • Integration of neurobiological and psychological models of pain.

Main Results:

Related Experiment Videos

  • Pain can be conceptualized as a complex output of the central nervous system, influenced by various factors beyond peripheral tissue damage.
  • A shift in thinking from "tissue-based" to "brain-based" pain offers a more comprehensive understanding.

Conclusions:

  • Rethinking pain in the absence of injury is crucial for advancing treatment strategies.
  • This new perspective may lead to more effective interventions for fibromyalgia and similar conditions.