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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Does prenatal stress alter the developing connectome?

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Summary
This summary is machine-generated.

Maternal prenatal stress impacts fetal brain wiring, affecting the human connectome. This can increase risks for neurodevelopmental disorders like autism and schizophrenia.

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Neuroimaging

Background:

  • Human neurodevelopment relies on the connectome, a network of neural connections.
  • Prenatal exposure to maternal stress may alter fetal brain wiring.
  • Maternal stress during pregnancy is linked to neurodevelopmental disorders.

Purpose of the Study:

  • To review how maternal stress physiology affects the developing human connectome.
  • To examine the impact on fetal brain structural and functional connectivity.

Main Methods:

  • Review of existing literature.
  • Focus on structural and functional connectivity imaging techniques.
  • Assessment of stress-related physiological changes in pregnant women.

Main Results:

  • Prenatal stress can lead to connectome miswiring.
  • Altered connectivity is associated with risks for various neurobehavioral disorders.
  • Imaging studies provide insights into these developmental changes.

Conclusions:

  • Maternal stress is a critical factor in fetal connectome development.
  • Understanding these impacts is crucial for preventing neurodevelopmental disorders.
  • Neuroimaging offers a window into stress-induced brain development.