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Intussusception hospitalizations incidence in the pediatric population in Italy: a nationwide cross-sectional study
Francesco Trotta1,2, Roberto Da Cas3, Antonino Bella3
1Pharmacovigilance Office, Italian Medicines Agency (AIFA), Via del Tritone 181, Rome, 00187, Italy. f.trotta@aifa.gov.it.
Insights
The incidence of pediatric intussusception in Italy was 21 per 100,000 children, with higher rates in infants and boys. Incidence rates remained stable from 2004 to 2012.
Area of Science:
- Pediatric Gastroenterology
- Epidemiology
- Public Health
Background:
- Investigating the incidence and temporal trends of intussusception in Italian children.
- Establishing a baseline for pediatric intussusception rates in Italy.
Purpose of the Study:
- To determine the incidence of intussusception in the pediatric population (0-15 years) in Italy.
- To analyze the temporal trends of intussusception incidence over an 11-year period.
- To provide data for post-marketing surveillance of rotavirus vaccinations.
Main Methods:
- Cross-sectional study utilizing national hospital discharge data from 2002-2012.
- Calculation of annual intussusception incidence rates, incidence rate ratios (IRRs), and 95% confidence intervals (CIs).
Main Results:
- Overall incidence rate of 21 per 100,000 children (≤15 years), higher in boys.
- Highest incidence in infants (<1 year) at 39 per 100,000.
- Infant incidence in central Italy was 50 per 100,000; rates were stable from 2004-2012.
Conclusions:
- Provides crucial intussusception incidence data for Italian pediatric populations, including infants.
- Essential for ongoing post-marketing safety surveillance of rotavirus vaccines.
- Supports continuous monitoring of the benefit/risk profile of rotavirus vaccinations.
Background:
Study to investigate the intussusception incidence background in the pediatric population and its temporal trend in Italy.
Methods:
A cross-sectional study was conducted on the pediatric population aged 0 to 15 years, in the period 1 January 2002 to 31 December 2012. Intussusception cases were identified using the national hospital discharge database. The annual intussusception incidence, the incidence rate ratios (IRRs) and the related 95 % confidence Intervals (CI) were calculated.
Results:
The overall intussusception incidence rate was 21 per 100,000 children aged ≤15 years, and was higher among boys than girls. The highest intussusception incidence rate occurred in infants <1 year of age (39 per 100,000 infants). Among infants, incidence varied with the geographical area, with higher rates in the central Italy (50 per 100,000 infants). The annual incidence rates in infants were stable since 2004 and up to 2012, ranging from 40.1 and 33.0 per 100,000 infants. Similar stable patterns were observed when conducting the analysis on children over 1 year of age.
Conclusions:
This study provided the intussusception incidence background in Italy in different pediatric ages, including infants, over an 11-year period. This information is essential in post-marketing safety surveillance, to continuously monitor the benefit/risk profile of rotavirus vaccinations.
