Related Experiment Video
Updated: Mar 14, 2026
08:34
Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat
Published on: November 18, 2018
7.8K
Pulmonary hypertension associated with chronic lung diseases
Manuela Funke1, Thomas Geiser1, Otto D Schoch2
1Department for Pulmonary Medicine, Inselspital, University Hospital Bern, University of Bern, Switzerland.
Swiss Medical Weekly
|September 30, 2016
Summary
Pulmonary hypertension (PH) in chronic lung diseases like COPD and ILD is challenging to treat. Current treatments for pulmonary arterial hypertension (PAH) may be harmful, and evidence-based therapies for PH in ILD or COPD are lacking.
Area of Science:
- Pulmonary Medicine
- Cardiology
- Respiratory Diseases
Background:
- Pulmonary hypertension (PH) is classified into groups, with Group 3 encompassing PH associated with chronic lung diseases such as COPD and ILD.
- PH in COPD and ILD presents management challenges due to limited evidence from randomized controlled trials (RCTs) with specific pulmonary arterial hypertension (PAH) drugs.
Purpose of the Study:
- To review the current understanding and management challenges of PH associated with chronic lung diseases.
- To discuss the potential risks and limited efficacy of existing PAH treatments in this patient population.
- To highlight the unmet need for evidence-based treatments for PH in ILD and COPD.
Main Methods:
- Literature review of international guidelines and clinical trials.
- Analysis of pathophysiological mechanisms linking PAH and fibrotic lung disease.
- Evaluation of past and emerging therapeutic strategies for PH in chronic lung conditions.
Main Results:
- No long-term RCT data exists for PAH-specific drugs in PH associated with COPD.
- A recent RCT in PH associated with ILD was halted early due to safety concerns and potential increased mortality.
- Existing PAH drugs may worsen gas exchange by increasing ventilation-perfusion mismatch in patients with chronic lung disease.
Conclusions:
- Specific PAH treatments may be harmful in PH associated with COPD and ILD.
- Current management requires careful consideration of individual pathophysiological mechanisms.
- There is a critical need for developing evidence-based, targeted treatments for PH in patients with ILD or COPD.
Related Concept Videos
01:30Pulmonary Hypertension: Classification and Pathogenesis
766
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
766
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
4.0K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
4.0K
01:24Chronic Obstructive Pulmonary Disease
2.9K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.9K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
4.0K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.0K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.0K
01:20COPD: Pathogenesis and Clinical Features
2.1K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.1K