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Related Experiment Videos

ABR threshold is a function of blood oxygen level.

H Sohmer1, S Freeman, M Schmuel

  • 1Department of Physiology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Hearing Research
|June 15, 1989
PubMed
Summary

Hypoxia, or low oxygen levels, can elevate auditory brainstem response (ABR) thresholds in cats, indicating potential hearing loss. This suggests premature human fetuses with in utero hypoxia may also experience sensorineural hearing impairment.

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Area of Science:

  • Auditory Neuroscience
  • Otolaryngology
  • Neonatal Physiology

Background:

  • Auditory threshold and oxygen availability are crucial for hearing function.
  • Hypoxia is a known risk factor for various physiological impairments.

Purpose of the Study:

  • To investigate the relationship between auditory threshold and oxygen availability.
  • To determine the impact of hypoxia on auditory brainstem response (ABR) in a mammalian model.

Main Methods:

  • Cats were anesthetized, paralyzed, and ventilated with varying oxygen concentrations.
  • Auditory nerve-brain stem evoked response (ABR) thresholds were measured.
  • Arterial blood oxygen levels (PaO2 and SaO2) were monitored.

Main Results:

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  • ABR thresholds remained stable when PaO2 was above 30 mm Hg (SaO2 > 45%).
  • Hypoxia caused reversible ABR threshold elevations between PaO2 20-30 mm Hg (SaO2 25-45%).
  • ABR threshold increased by approximately 3.05 dB per mmHg decrease in PaO2.

Conclusions:

  • Hypoxia induces a depression of the endocochlear potential, affecting auditory thresholds.
  • Findings suggest premature neonates (≥28 weeks gestation) with fetal hypoxia may have sensorineural hearing loss.
  • This study highlights the vulnerability of the developing auditory system to oxygen deprivation.