The future of multiple sclerosis treatments

Area of Science:

• Neurology
• Immunology
• Neuroscience

Background:

• Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease affecting the central nervous system.
• Significant advancements in disease-modifying treatments (DMTs) have been made over the past decades.
• Current DMTs primarily target the inflammatory phase of MS.

Purpose of the Study:

• To review existing and emerging DMTs for multiple sclerosis.
• To discuss the role of these therapies within various MS treatment strategies.
• To highlight unmet needs in MS treatment, particularly neuroprotection and disability halting.

Main Methods:

• Literature review of available scientific data on MS treatments.
• Analysis of current and future therapeutic strategies for MS.
• Synthesis of information on DMTs, neurodegeneration, and treatment sequencing.

Main Results:

• A range of DMTs are available for managing MS inflammation.
• Effective treatments for halting neurodegeneration and disability progression in MS are still lacking.
• Emerging DMTs show promise but require further investigation.

Conclusions:

• Future MS treatment strategies must focus on combating disease progression and neurodegeneration.
• A deeper understanding of DMT side-effects and optimal sequential use is essential.
• Integrated treatment approaches combining existing and novel therapies are crucial for improved MS management.