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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Cancer Stem Cells and Tumor Maintenance02:40

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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
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Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
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Future Prospects in Breast Cancer Research - Cancer Stem Cells.

Floor Wolbers1, Henk R Franke2, Joost M Klaase3

  • 1BIOS, Lab on a Chip Group, MESA+ Institute for Nanotechnology, University of Twente , Enschede, The Netherlands.

EJIFCC
|September 30, 2016
PubMed
Summary

This study introduces novel microfluidic methods to target both differentiated tumor cells and drug-resistant cancer stem cells (CSCs) in breast cancer. These approaches aim to improve treatment efficacy and reduce breast cancer mortality by addressing CSC-mediated recurrence.

Keywords:
apoptosisbreast cancercancer stem celldrug screeningmammospheresmicrofluidics

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Area of Science:

  • Oncology
  • Biotechnology
  • Medical Engineering

Background:

  • Breast cancer remains a leading cause of female mortality despite advances in treatment.
  • Cancer stem cells (CSCs) contribute to tumor heterogeneity, chemoresistance, and metastasis.
  • Current therapies often spare CSCs, leading to disease recurrence.

Purpose of the Study:

  • To develop novel therapeutic strategies targeting both differentiated tumor cells and cancer stem cells (CSCs) in breast cancer.
  • To investigate the potential of microfluidics for personalized breast cancer treatment.
  • To improve disease-free survival by specifically eliminating CSCs.

Main Methods:

  • Development of an 'Apoptosis chip' to target differentiated tumor cells.
  • Design of a microfluidic system for specific targeting of cancer stem cells (CSCs).
  • Utilizing microfluidics for precise and personalized therapeutic interventions.

Main Results:

  • The study describes two distinct microfluidic methods for distinct breast cancer cell populations.
  • These methods are designed to overcome CSC resistance to conventional therapies.
  • The approach aims to enhance the effectiveness of breast cancer treatment regimens.

Conclusions:

  • Targeting cancer stem cells (CSCs) is crucial for improving breast cancer patient outcomes.
  • Microfluidic technologies offer promising avenues for developing targeted breast cancer therapies.
  • The described methods have the potential to reduce breast cancer recurrence and metastasis.