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Cystatin C in Acute Coronary Syndrome
Moushumi Lodh1, Ashok Parida2, Joy Sanyal3
1MD Biochemistry, The Mission Hospital , Durgapur, West Bengal, India.
Insights
Serum cystatin C levels are linked to coronary artery disease (CAD) even in individuals with normal kidney function. This marker may help identify higher CAD risk in low-risk populations.
Area of Science:
- Nephrology
- Cardiology
- Biomarkers
Background:
- Cystatin C is a sensitive marker for renal function.
- Its role in predicting cardiovascular events in impaired renal function is established.
- The association between cystatin C and coronary artery disease (CAD) in patients with normal kidney function requires further investigation.
Purpose of the Study:
- To assess the association between serum cystatin C levels and CAD in patients with normal kidney function.
- To evaluate cystatin C's ability to identify individuals at higher risk for CAD within a low-risk category (based on estimated glomerular filtration rate).
Main Methods:
- Analysis of serum cystatin C levels in a consecutive series of patients.
- Coronary artery disease assessment.
- Statistical analysis to determine independent associations, controlling for overt renal insufficiency.
Main Results:
- Serum cystatin C levels were independently associated with the development of CAD.
- This association was observed even in patients with normal kidney function.
Conclusions:
- Serum cystatin C is independently associated with CAD.
- Cystatin C may serve as a valuable biomarker for identifying CAD risk, even in individuals with seemingly normal renal function.
Abstract:
Cystatin C has been regarded as a novel sensitive marker for the assessment of renal function, and the role of cystatin C as a predictor of cardiovascular events in patients with impaired renal function has been confirmed in clinical studies. In this study we assessed the association between cystatin C and Coronary artery disease [CAD] in a consecutive series of patients with normal kidney function in order to avoid the well-known effect of overt renal insufficiency on coronary atherosclerosis, and evaluate whether cystatin C has an ability to identify individuals at a higher risk for CAD among patients belonging to a low-risk category according to estimated glomerular filtration rate .The current study and review of literature demonstrated that serum levels of cystatin C, were independently associated with the development of CAD.
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