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Halitosis and helicobacter pylori infection: A meta-analysis
Wenhuan Dou1, Juan Li, Liming Xu
1Department of Gastroenterology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, People's Republic of China.
Helicobacter pylori (H pylori) infection is strongly linked to halitosis. Eradicating H pylori significantly reduces bad breath, suggesting it plays a role in the condition.
Area of Science:
- Gastroenterology
- Oral Medicine
Background:
- Halitosis, or bad breath, is a common condition with various potential causes.
- Helicobacter pylori (H pylori) infection has been investigated as a potential contributor to halitosis.
Purpose of the Study:
- To determine the correlation between H pylori infection and halitosis.
- To assess the effectiveness of H pylori eradication therapy in improving halitosis.
Main Methods:
- A comprehensive meta-analysis was conducted, searching multiple electronic databases up to December 2015.
- Included studies were published in English and Chinese, with data extraction and quality assessment performed independently and in duplicate.
Main Results:
- The analysis of 21 studies revealed a significant association between H pylori infection and halitosis (OR=2.85, P=0.004).
- Successful H pylori eradication therapy led to a substantial reduction in halitosis (RR=0.17, P<0.0001).
Conclusions:
- There is clear evidence linking H pylori infection to halitosis.
- H pylori may be a significant factor in the pathophysiology of halitosis, and eradication therapy could be a viable treatment for persistent cases.
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