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Different interventions in preventing opioid-induced cough: a meta-analysis
Li Shuying1, Li Ping1, Ni Juan1
1Department of Anesthesiology, West China Second Hospital of Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu 610041, China.
Journal of Clinical Anesthesia
|October 1, 2016
Summary
Opioid-induced cough (OIC) is common. Lidocaine, ketamine, dexmedetomidine, fentanyl priming, propofol, and dezocine effectively prevent OIC, according to this meta-analysis.
Area of Science:
- Anesthesiology and Pharmacology
- Critical Care Medicine
Background:
- Opioid-induced cough (OIC) is a frequent complication of opioid administration.
- Existing research on OIC prevention strategies presents conflicting findings.
- This study addresses the controversy by evaluating various interventions for OIC.
Purpose of the Study:
- To systematically assess the efficacy of different pharmacological interventions in preventing opioid-induced cough (OIC).
- To provide evidence-based recommendations for OIC management.
Main Methods:
- A comprehensive literature search was conducted across Cochrane CENTRAL, PubMed, and Embase databases.
- Randomized controlled trials (RCTs) investigating drugs for OIC prevention were included.
- Data on OIC incidence and severity following interventions with specific opioids (fentanyl, sufentanil, remifentanil) were analyzed.
Main Results:
- Thirty-four RCTs involving 9906 patients were analyzed.
- Lidocaine, ketamine, dexmedetomidine, fentanyl priming, propofol, dezocine, dexamethasone, dextromethorphan, and magnesium sulfate demonstrated significant efficacy in preventing OIC.
- Salbutamol, tramadol, midazolam, and atropine were found to be ineffective.
Conclusions:
- Prophylactic administration of lidocaine, ketamine, dexmedetomidine, fentanyl priming, propofol, and dezocine is effective in preventing OIC.
- Further research is needed for drugs with insufficient trial data.
- These findings support the use of specific agents for OIC prophylaxis.
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