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Whole-body PET/MRI of Pediatric Patients: The Details That Matter
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PET/CT in paediatric malignancies - An update.

Subramanyam Padma1, Palaniswamy Shanmuga Sundaram1, Anshu Tewari1

  • 1Department of Nuclear Medicine and PET/CT, Amrita Institute of Medical Sciences, Cochin, Kerala, India.

Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology
|October 1, 2016
PubMed
Summary

(18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) offers valuable insights into pediatric cancers. This review details its use in staging, therapy assessment, and follow-up for childhood solid tumors, distinct from hematological malignancies.

Keywords:
Central nervous system tumorschildhood malignanciesneuroblastomapositron emission tomography/computed tomographysarcoma

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Area of Science:

  • Nuclear Medicine
  • Pediatric Oncology
  • Medical Imaging

Background:

  • (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) is standard in adult oncology.
  • Pediatric malignancies present unique challenges including different tumor biology, FDG uptake patterns, smaller body mass, and dosimetric considerations.
  • Specialized planning and expertise are crucial for pediatric PET/CT studies.

Purpose of the Study:

  • To review the established and emerging applications of FDG-PET/CT in pediatric solid tumors.
  • To highlight the differences and considerations for FDG-PET/CT in children compared to adults.
  • To underscore the utility of FDG-PET/CT in staging, response assessment, metastasis detection, and follow-up of pediatric malignancies.

Main Methods:

  • Literature review focusing on FDG-PET/CT applications in non-hematological pediatric cancers.
  • Analysis of studies examining FDG uptake patterns and diagnostic performance in childhood malignancies.
  • Synthesis of information regarding the practical aspects of conducting pediatric PET/CT.

Main Results:

  • FDG-PET/CT is effective for staging, assessing therapy response, identifying metastases, and follow-up in various pediatric solid tumors.
  • Distinct physiological and biological factors influence FDG uptake in children, necessitating tailored protocols.
  • The review covers applications in diverse pediatric malignancies excluding lymphoma and leukemia.

Conclusions:

  • FDG-PET/CT plays a significant role in managing pediatric solid tumors.
  • Careful patient preparation and expert interpretation are vital for successful pediatric PET/CT.
  • Further research may refine the role of FDG-PET/CT in specific pediatric cancer types.