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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease V: Surgical Management01:21

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Large Intestine01:09

Large Intestine

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The large intestine is divided into three main regions: the cecum, colon, and rectum. Extending from the ileocecal valve to the anus, it frames the small intestine on three sides.
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Related Experiment Video

Updated: Mar 14, 2026

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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Segmental colitis associated diverticulosis syndrome.

Hugh J Freeman1

  • 1Hugh J Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, BC V6T 1W5, Canada.

World Journal of Gastroenterology
|October 1, 2016
PubMed
Summary

Segmental colitis associated diverticulosis (SCAD) is an inflammatory colon condition primarily affecting older males, often presenting with rectal bleeding. This distinct disorder typically localizes to the sigmoid colon and frequently resolves spontaneously or with minimal treatment.

Keywords:
DiverticulitisDiverticulosisInflammatory bowel diseaseSegmental colitisSegmental colitis associated diverticulosis syndromeUlcerative colitis

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Area of Science:

  • Gastroenterology
  • Colorectal Surgery
  • Pathology

Background:

  • Segmental colitis associated diverticulosis (SCAD) is increasingly recognized as a distinct colonic inflammatory disease.
  • It predominantly affects older males, localized mainly to the sigmoid colon.
  • SCAD presents with rectal bleeding and non-specific inflammatory changes on biopsy, differentiating it from Crohn's disease.

Discussion:

  • The localized nature and "rectal sparing" are key diagnostic features of SCAD.
  • Absence of granulomas and negative infectious studies aid in distinguishing SCAD.
  • SCAD's typical self-limited course contrasts with other chronic inflammatory bowel diseases.

Key Insights:

  • SCAD is characterized by inflammation predominantly in the sigmoid colon with rectal sparing.
  • Histopathology shows non-specific inflammation, and granulomas are absent.
  • Most SCAD cases resolve spontaneously or with 5-aminosalicylate treatment.

Outlook:

  • Further research may clarify SCAD's pathogenesis and optimal management strategies.
  • Understanding SCAD's distinct features can improve diagnostic accuracy and patient care.
  • While often self-limiting, occasional cases may require corticosteroids or surgery.