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Published on: June 23, 2020
Synthesis and Evaluation of Paclitaxel-Loaded Gold Nanoparticles for Tumor-Targeted Drug Delivery
Giulio F Paciotti1, Jielu Zhao2, Shugeng Cao2
1CytImmune Sciences Inc. , 15010 Broschart Road, Rockville, Maryland 20850, United States.
Abstract:
The synthesis of a series of thiolated paclitaxel analogs is described as part of a novel nanomedicine program aimed at developing formulations of paclitaxel that will bind to gold nanoparticles for tumor targeted drug delivery. Preliminary evaluation of the new nanomedicine composed of 27 nm gold nanoparticles, tumor necrosis factor alpha (TNFα), thiolated polyethylene glycol (PEG-thiol), and one of several thiolated paclitaxel analogs is presented.
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