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Diketopiperazines from marine-derived Exserohilum sp. M1-6
Rui Xu1, Jianjian Wang1, Changyu Liu2
1Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Engineering Research Center of Low-carbon and High-quality Utilization of Forest Biomass, University of Guangxi, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning, China.
None:
A new diketopiperazine (1) and 11 known compounds (2-12) were isolated from marine-derived Exserohilum sp. M1-6. The structure and the absolute configuration of compound 1 were determined by NMR, HRESIMS and electronic circular dichroism (ECD) data. The pro-angiogenic activity of compounds 2-12 were evaluated on the basis of a zebrafish model. The results showed that compounds 3, 11 and 12 had pro-angiogenic activity at a concentration of 40 μM.
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