Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 8, 2026

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

ROS-Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief.

Meng Zheng1, Changyu Liu1, Qin Xia1

  • 1Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 6, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chiral D/L-His@Cu NPs with peroxidase-like activity for colorimetric detection of D/L-DOPA.

Analytical methods : advancing methods and applications·2026
Same author

ScopeViewer: A Browser-Based Solution for Visualizing Large Biological Images.

GigaScience·2026
Same author

Denis pattern-dependent biomechanical behavior of posterior trans-iliac plate fixation compared with bilateral triangular osteosynthesis in unilateral sacral fractures: a finite element study.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2026
Same author

MicNet: integrating spatially resolved transcriptomes and pathology images by contrastive deep neural network.

Genome biology·2026
Same author

Systemic-to-local nanorobot thrombolysis.

Science advances·2026
Same author

Acupoint Application for Constipation in Thoracolumbar Compression Fracture.

Journal of visualized experiments : JoVE·2026
This summary is machine-generated.

New Janus nanomotors deliver metformin directly to joints, targeting inflammation and pain in osteoarthritis (OA). These self-propelled nanomotors scavenge reactive oxygen species (ROS) and protect cartilage for improved arthritis management.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Pharmacology

Background:

  • Osteoarthritis (OA) presents significant challenges due to limited effective treatments and the side effects of systemic drug administration.
  • Current intra-articular injections for OA face issues with rapid clearance and poor tissue penetration, hindering therapeutic efficacy.
  • Joint inflammatory pain is a major concern for OA patients, necessitating innovative pain management strategies.

Purpose of the Study:

  • To develop novel nanozyme-based Janus nanomotors loaded with metformin (MET) for targeted reactive oxygen species (ROS)-mediated therapy in osteoarthritis.
  • To leverage the self-propelling capabilities of nanomotors for enhanced deep tissue penetration and sustained drug delivery within the joint.
  • To investigate the potential of these nanomotors in scavenging ROS, protecting chondrocytes, and alleviating joint pain.
Keywords:
NRF2metforminnanomotorosteoarthritispain

Related Experiment Videos

Last Updated: Jul 8, 2026

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
05:50

Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles

Published on: June 2, 2023

Main Methods:

  • Fabrication of nanozyme-based Janus nanomotors incorporating metformin (MET).
  • Utilizing intrinsic superoxide dismutase (SOD) and catalase (CAT) activity to harness ROS as fuel for self-propulsion.
  • Evaluating nanomotor penetration into cartilage and synovial tissue, ROS scavenging, MET release kinetics, and chondrocyte protection via NRF2/KEAP1 pathway modulation.
  • Assessing the suppression of nociceptive signaling in dorsal root ganglia (DRG) to evaluate pain relief and mobility improvement.

Main Results:

  • The developed nanomotors demonstrated self-propelled deep penetration into cartilage and synovial tissue, driven by ROS.
  • Simultaneous ROS scavenging and sustained MET release were achieved, restoring redox homeostasis and protecting chondrocytes.
  • Nanomotors effectively regulated the NRF2/KEAP1 signaling pathway, crucial for chondrocyte protection.
  • Therapeutic intervention successfully suppressed nociceptive signaling in DRG, leading to significant joint pain alleviation and improved mobility.

Conclusions:

  • Nanozyme-based Janus nanomotors offer a promising platform for targeted OA therapy by utilizing ROS as a fuel source.
  • This approach enables efficient deep-tissue drug delivery, ROS scavenging, and chondrocyte protection, addressing key limitations of current OA treatments.
  • The nanomotors provide a novel and effective strategy for managing osteoarthritis pain and protecting cartilage, paving the way for improved patient outcomes.