Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

ROS-Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Nacre-Inspired Flexible Mxene-Based Films for Multifunctional Applications in Supercapacitors and Piezoresistive Sensors.

Sensors (Basel, Switzerland)·2026

Same author

"<i>Z</i>-Axis" Thinking: Structural Coding Enables Programmable Motion of Catalytic Micromotors.

ACS applied materials & interfaces·2026

Same author

Non-Close-Packed Isotropic Responsive Magnetic Photonic Crystal Microspheres.

Nanomaterials (Basel, Switzerland)·2026

Same author

Interface electron transfer driven H<sub>2</sub>O<sub>2</sub> activation over a MOF-derived Fe<sub>3</sub>O<sub>4</sub>-FeM/C cathode for efficient electro-Fenton degradation of tetracycline.

Journal of environmental management·2026

Same author

Exceptional Specific Shielding Effectiveness of TOCNFs@MXene Hybrid Films via Densification Engineering.

Polymers·2026

Search research articles

Related Experiment Video

Updated: May 22, 2026

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

Published on: September 25, 2016

Systemic-to-local nanorobot thrombolysis.

Di Zhang¹, Ouling Zhu², Fangzhi Mou^1,3

¹State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, P. R. China.

Science Advances

|May 20, 2026

Summary

This summary is machine-generated.

New magnetic nanorobots offer safe, systemic thrombolysis. These polyvinyl pyrrolidone-coated iron oxide nanorobots target clots, degrade rapidly, and avoid toxicity, overcoming key challenges in nanorobotic therapy.

More Related Videos

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

Related Experiment Videos

Last Updated: May 22, 2026

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli

Published on: September 25, 2016

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo

Published on: December 19, 2025

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Magnetic nanorobots show potential for targeted thrombolysis.
Current limitations include rapid immune clearance, poor degradability, and invasive deployment.

Purpose of the Study:

To develop safe and versatile magnetic nanorobots for systemic-to-local thrombolysis.
To overcome translational challenges in nanorobotic therapy.

Main Methods:

Constructed nanorobots from polyvinyl pyrrolidone-shielded porous Fe3O4 colloidal nanocrystal clusters (p-Fe3O4@PVP CNCs).
Utilized PVP coating for tissue plasminogen activator (tPA) loading and prolonged circulation.
Employed magnetic fields for nanorobot collection and actuation for targeted thrombolysis.
Investigated degradation and clearance pathways post-thrombolysis.

Main Results:

The p-Fe3O4@PVP CNCs facilitated efficient tPA loading and extended circulation time.
Magnetic fields enabled precise collection and navigation for targeted thrombolysis.
Nanorobots disassembled upon removal of the actuation field into rapidly degrading CNCs.
Clearance occurred primarily via the liver-bile-intestine axis with no observed long-term toxicity.

Conclusions:

This nanorobot platform enables safe and versatile systemic thrombolysis.
The design overcomes key challenges of immune clearance and degradability.
The technology presents a promising approach for future nanorobotic therapeutic applications.