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Strategies for improving drug delivery: nanocarriers and microenvironmental priming

Ayesha Khalid1, Stefano Persano2, Haifa Shen2,3

  • 1a Medical Program, Weill Cornell Medicine-Qatar , Qatar Foundation , Doha , Qatar.

Expert Opinion on Drug Delivery
|October 1, 2016
PubMed
Abstract

Insights

Improving drug delivery to diseased tissues is crucial for effective cancer treatment. This review explores nanocarrier and priming strategies to overcome biological barriers, enhancing drug biodistribution and reducing side effects.

Area of Science:

  • Oncology
  • Drug Delivery
  • Biophysics

Background:

  • Achieving targeted drug delivery to pathological tissues is a primary challenge in medicine.
  • Current strategies often focus on nanocarriers for preferential drug accumulation in diseased sites.
  • Transport oncophysics is an emerging discipline addressing these challenges in cancer therapy.

Purpose of the Study:

  • To review strategies for improving drug biodistribution and overcoming biological transport barriers.
  • To discuss both nanocarrier design and priming strategies for enhanced drug delivery.
  • To explore the potential of combining these approaches for optimal therapeutic outcomes.

Main Methods:

  • Review of existing literature on nanocarrier-based drug delivery.
  • Analysis of priming strategies that modulate the biological environment for localized delivery.
  • Discussion of nanoparticle design principles for improved targeting.

Main Results:

  • Nanocarriers facilitate preferential accumulation of drugs in diseased tissues.
  • Priming strategies offer a less common but promising approach to enhance localized drug delivery.
  • Combinations of priming agents and nanocarriers show potential for optimal drug distribution.

Conclusions:

  • Priming strategies represent a promising solution for overcoming biological transport barriers in drug delivery.
  • Modulating the biological environment, including healthy tissue, can reduce off-target nanoparticle uptake.
  • Integrated approaches combining nanocarriers and priming are likely to yield superior drug distribution profiles.
Keywords:
Biodistributionbiological barriernanodelivery systempriming agentstransport ocophysics

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