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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Published on: November 4, 2010

Characterization of bronchiectasis in the elderly.

Giuseppe Bellelli¹, James D Chalmers², Giovanni Sotgiu³

¹School of Medicine and Surgery, University of Milan Bicocca, Geriatric Unit, ASST San Gerardo, Via Pergolesi 33, Monza, Italy.

Respiratory Medicine

|October 4, 2016

Summary

Older adults with bronchiectasis experience worse outcomes due to frailty, not disease differences. Key mortality predictors include age, low BMI, prior hospitalizations, and reduced FEV1.

Keywords:

COPD Comorbidity Cystic fibrosis Frailty Pseudomonas

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Area of Science:

Pulmonology
Geriatrics
Epidemiology

Background:

Bronchiectasis commonly affects individuals aged 65 and older.
Limited data exists on the clinical characteristics and outcomes of bronchiectasis in this demographic.

Purpose of the Study:

To evaluate the clinical features of bronchiectasis in older adults and the elderly.
To assess the clinical outcomes, including mortality, in different age groups of bronchiectasis patients.

Main Methods:

Secondary analysis of six European prospective databases of adult outpatients with bronchiectasis.
Comparison of bronchiectasis characteristics across three age groups: younger adults (18-65), older adults (66-75), and elderly (≥76).
Primary outcome was 3-year mortality.

Main Results:

Elderly patients (≥76 years) exhibited higher comorbidity, poorer quality of life, and increased mortality.
No significant differences were found in etiology, severity, or *Pseudomonas aeruginosa* infection prevalence across age groups.
Independent predictors of 3-year mortality included older age, low body mass index (BMI), previous hospitalizations, and decreased forced expiratory volume in 1 second (FEV1).

Conclusions:

Bronchiectasis presentation and severity do not substantially vary by age group.
Poorer outcomes in elderly patients are likely linked to individual frailty, warranting further investigation.