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Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

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Published on: August 8, 2025

Serial Changes in Cognitive Function Following Transcatheter Aortic Valve Replacement.

Vincent Auffret¹, Francisco Campelo-Parada¹, Ander Regueiro¹

¹Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada.

Journal of the American College of Cardiology

|October 4, 2016

Summary

This summary is machine-generated.

Transcatheter aortic valve replacement (TAVR) improved global cognition in patients, especially those with pre-existing impairment. However, some experienced early cognitive decline post-TAVR, with 10% showing persistent issues at one year.

Keywords:

aortic stenosis cerebral embolization cognition dementia stroke

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Published on: June 3, 2018

Area of Science:

Cardiology
Neurology
Geriatrics

Background:

Limited data exists on the long-term cognitive changes in patients undergoing transcatheter aortic valve replacement (TAVR).
Understanding cognitive trajectory post-TAVR is crucial for patient management and outcomes.

Purpose of the Study:

To evaluate changes in global cognition and specific cognitive domains up to one year after TAVR.
To identify the incidence and persistence of cognitive decline or improvement following TAVR.

Main Methods:

Fifty-one patients (median age 80) underwent TAVR and cognitive assessments (MoCA, DSST, TMT, verbal fluency) at baseline, 30 days, and 1 year.
Cognitive decline was determined using mean score changes and the reliable change index (RCI).

Main Results:

Mean MoCA scores improved short-term post-TAVR and remained stable at 1 year. Cognitive improvement was noted in 7.8% of patients, particularly those with baseline impairment.
While global cognition improved, 25% of patients showed decline in at least one cognitive test at 30 days, persisting in 10% at 1 year.

Conclusions:

TAVR is associated with overall cognitive improvement, especially in patients with pre-existing cognitive impairment.
A subset of TAVR recipients experiences early decline in complex cognitive functions, with a portion showing persistent deficits at one year.