Related Experiment Video
Updated: Mar 14, 2026
Sub-acute Cerebral Microhemorrhages Induced by Lipopolysaccharide Injection in Rats
Published on: October 17, 2018
Thrombotic Thrombocytopenic Purpura with Concomitant Progressive Cerebral Microbleeds
Nariman Noorbakhsh-Sabet1, Ramin Zand2
1Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee.
Abstract:
Thrombotic thrombocytopenic purpura (TTP) is a disease caused by excessive platelet thrombi and multisystem vasculopathy. We report a young patient with refractory TTP who has developed multiple multifocal cerebral microbleeds on his brain magnetic resonance imaging scans. TTP-associated thrombotic microangiopathy resulting in diffuse microthrombi formation in the microcirculation and hypoperfusion might be an underlying etiology.
Insights
Thrombotic thrombocytopenic purpura (TTP) can cause cerebral microbleeds. This case report highlights multifocal brain microhemorrhages in a patient with refractory TTP, suggesting microvascular thrombosis as a potential cause.
Area of Science:
- Neurology
- Hematology
- Pathology
Background:
- Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and organ damage.
- TTP pathogenesis involves dysregulation of von Willebrand factor, leading to platelet aggregation and microthrombi formation.
Observation:
- A young patient with refractory TTP presented with new-onset neurological symptoms.
- Brain magnetic resonance imaging (MRI) revealed multiple, multifocal cerebral microbleeds.
Findings:
- The cerebral microbleeds in this TTP patient suggest a link between TTP-associated thrombotic microangiopathy and intracranial hemorrhage.
- Diffuse microthrombi in the cerebral microcirculation and resultant hypoperfusion are potential underlying mechanisms.
Implications:
- This case expands the spectrum of neurological manifestations associated with TTP.
- Understanding the link between TTP and cerebral microbleeds may inform diagnostic and therapeutic strategies for TTP patients with neurological complications.
