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Updated: Mar 14, 2026
08:58
Murine Kidney Transplant Technique
Published on: October 20, 2015
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[Pediatric kidney transplantation].
L Badet1, X Matillon1, R Codas1
1Service d'urologie et de chirurgie de la transplantation, HCL, hôpital Édouard-Herriot, université Claude-Bernard Lyon 1, 5, place d'Arsonval, 69437 Lyon cedex 03, France.
Summary
Pediatric kidney transplantation offers superior graft survival compared to adults, though viral infections and non-compliance pose risks. Surgical techniques are standardized for optimal outcomes in children with end-stage renal disease.
Area of Science:
- Pediatric Nephrology
- Transplant Surgery
- Immunology
Background:
- End-stage renal disease (ESRD) in children necessitates advanced treatment options.
- Kidney transplantation is the preferred treatment for pediatric ESRD.
- Understanding surgical nuances and outcomes is crucial for improving pediatric renal replacement therapy.
Purpose of the Study:
- To comprehensively review the indications, surgical techniques, results, and outcomes of kidney transplantation in pediatric patients.
- To highlight advancements and challenges in pediatric kidney transplantation.
Main Methods:
- Systematic literature review of Medline and Embase databases.
- Inclusion of studies published in English or French within the last 10 years.
- Analysis of prospective, retrospective studies, reviews, meta-analyses, and guidelines.
Main Results:
- Kidney transplantation is the gold standard for pediatric ESRD.
- Standardized surgical approaches (retroperitoneal or transperitoneal) are employed based on patient and graft size.
- Techniques like Campos Freire for ureteral reimplantation are common; adaptations are made for specific recipient conditions.
Conclusions:
- Pediatric kidney transplant graft survival rates have significantly improved and now surpass adult rates, especially with experienced microsurgical teams.
- Immunosuppressive protocols are similar to adults, but viral infections and post-transplant lymphoproliferative disorder are major complications.
- Graft loss increases in boyhood, often linked to non-compliance with immunosuppressive therapy.
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