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Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Historical developments in children's deep brain stimulation.

Laura Cif¹, Philippe Coubes²

¹Unités de Neurochirurgie Fonctionnelle et Pédiatrique, Département de Neurochirurgie, Centre Hospitalier Universitaire Montpellier, France; Unité de Recherche sur les Comportements et Mouvements Anormaux (URCMA), France; Institut de Génomique Fonctionnelle, Centre National de la Recherche Scientifique, Unité Mixte de la Recherche 5203, France; Université Montpellier, 34000, Montpellier, France; Laboratoire de Recherche en Neurosciences Cliniques (LRENC), France.

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society

|October 4, 2016

Summary

This summary is machine-generated.

Deep brain stimulation (DBS) offers an adjustable and efficient therapy for childhood dystonia, improving daily function. Further research is needed to confirm its long-term efficacy in various dystonia types.

Keywords:

Deep brain stimulation Developments Dystonia Paediatrics

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Area of Science:

Neurology
Neurosurgery
Pediatrics

Background:

Childhood onset dystonia is progressive, causing significant disability.
There is a critical need for effective symptomatic treatments.
Dystonia presents with diverse pathobiology and clinical features.

Purpose of the Study:

To evaluate deep brain stimulation (DBS) as a therapeutic option for childhood onset dystonia.
To explore the efficacy of DBS in various forms of dystonia.
To investigate the role of DBS in severe dystonic conditions like status dystonicus.

Main Methods:

Deep brain stimulation (DBS) targeting basal ganglia (BG) and thalamus, specifically the internal segment of the globus pallidus (GPi).
Exploration of concurrent targets like the subthalamic nucleus (STN) and thalamic motor nuclei.
DBS programming adapted from adult protocols for the pediatric population.

Main Results:

DBS is highly efficient for primary dystonia and associated symptoms like subcortical myoclonus.
DBS shows potential as a first-line therapy for life-threatening status dystonicus.
Efficacy in acquired, neurometabolic, and degenerative dystonia requires further investigation due to pathobiological complexity.

Conclusions:

DBS provides effective symptomatic relief for severe pediatric dystonia.
DBS enhances understanding of neural network dysfunction in dystonia and other movement disorders.
Further research is needed to establish selection criteria and optimize DBS for pediatric dystonia.