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Updated: Mar 14, 2026

Herbs-Partitioned Moxibustion on the Navel in a Rat Model of Primary Dysmenorrhea with Cold Coagulation and Blood Stasis
Published on: October 4, 2024
Factors Associated with Increased Pain in Primary Dysmenorrhea: Analysis Using a Multivariate Ordered Logistic
María I Tomás-Rodríguez1, Antonio Palazón-Bru2, Damian R J Martínez-St John3
1Department of Pathology and Surgery, Miguel Hernández University, San Juan de Alicante, Alicante, Spain.
This study found that heavier menstrual flow, poorer quality of life, and medication use are linked to severe primary dysmenorrhea (PD) pain in young women. These factors offer new insights into managing intense menstrual pain.
Area of Science:
- Gynecology
- Pain Management
- Public Health
Background:
- Primary dysmenorrhea (PD) is a common condition affecting women of reproductive age.
- Previous studies often treated pain as binary or focused only on diagnosed PD patients.
- A detailed pain gradient assessment is needed to understand factors contributing to severe PD pain.
Purpose of the Study:
- To identify factors associated with intense pain in young women experiencing primary dysmenorrhea.
- To utilize a detailed pain grading scale to assess PD severity.
- To contribute novel findings to the understanding of PD pain intensity.
Main Methods:
- A cross-sectional observational study was conducted.
- 306 women aged 18-30 years at a Spanish University participated in 2016.
- Participants completed a questionnaire assessing factors related to dysmenorrhea, with pain graded using the Andersch and Milsom scale (0-3).
Main Results:
- Higher menstrual flow was significantly associated with more extreme pain (OR, 2.11; P < .001).
- Worse quality of life correlated with increased pain intensity (OR, 0.97; P < .001).
- Medication use for PD showed a strong association with severe pain (OR, 8.22; P < .001).
Conclusions:
- This study identified key factors associated with extreme primary dysmenorrhea pain.
- Heavier menstrual flow, reduced quality of life, and medication use are significant indicators of severe PD.
- Further research is recommended to validate these findings and inform clinical practice.
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