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Cluster headache and depression.

Mark A Louter1, Leopoldine A Wilbrink1, Joost Haan1

  • 1From the Departments of Neurology (M.A.L., L.A.W., J.H., W.P.J.v.O., M.D.F., G.M.T.), Psychiatry (M.A.L., F.G.Z.), and Biostatistics (E.W.v.Z.), Leiden University Medical Centre; Department of Neurosurgery (L.A.W.), Maastricht University Medical Centre; and Department of Neurology (J.H.), Alrijne Hospital, Leiderdorp, the Netherlands.

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|October 4, 2016
PubMed
Summary
This summary is machine-generated.

Cluster headache (CH) patients have nearly three times higher odds of lifetime depression. Current depression in active CH is linked to sleep disturbances from nocturnal attacks.

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Area of Science:

  • Neurology
  • Psychiatry
  • Epidemiology

Background:

  • Cluster headache (CH), known as "suicide headache," has a significant impact on patient well-being.
  • Depression is a serious comorbidity that warrants investigation in CH populations.

Purpose of the Study:

  • To determine the prevalence of depression in cluster headache patients.
  • To explore the relationship between depression, sleep disturbances, and CH characteristics.

Main Methods:

  • A cross-sectional, web-based study involving 462 CH patients and 177 controls.
  • Diagnosis of CH followed International Classification of Headache Disorders, 3rd edition (ICHD-III) criteria.
  • Depression was assessed using validated scales (HADS-D, CES-D) and lifetime depression questionnaires.

Main Results:

  • CH patients exhibited nearly 3 times higher odds of lifetime depression compared to controls (OR 2.77).
  • Chronic CH patients reported higher rates of lifetime depression and sleep problems than episodic CH patients.
  • Current depression was associated with active CH attacks but this link diminished after accounting for sleep disturbances.

Conclusions:

  • Cluster headache is strongly associated with an increased risk of lifetime depression.
  • Active cluster headache, particularly with nocturnal attacks, is linked to high current depression rates, partly due to associated sleep disturbances.