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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Regulation of Metabolism01:19

Regulation of Metabolism

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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Overview of Metabolism01:40

Overview of Metabolism

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Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
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Updated: Mar 14, 2026

Autofluorescence Imaging to Evaluate Cellular Metabolism
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Autofluorescence Imaging to Evaluate Cellular Metabolism

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Epigenetics and Cellular Metabolism.

Wenyi Xu1, Fengzhong Wang1, Zhongsheng Yu2

  • 1Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing, China.

Genetics & Epigenetics
|October 4, 2016
PubMed
Summary
This summary is machine-generated.

Epigenetic machinery regulates cellular metabolism and its dysfunction contributes to metabolic disorders. Manipulating metabolites offers a novel strategy to target epigenetic processes and disease progression.

Keywords:
DNA methylationcellular metabolismepigeneticshistone modificationsmetabolitesmicroRNA

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Area of Science:

  • Cellular biology
  • Metabolism
  • Epigenetics

Background:

  • Eukaryotic cells utilize complex mechanisms to respond to environmental signals.
  • Epigenetic machinery, including DNA methylation and histone modifications, is crucial for translating external stimuli into cellular responses.
  • Epigenetic signatures are vital for maintaining cellular metabolism, and metabolites can influence epigenetic memory.

Approach:

  • This review summarizes current research on the epigenetic regulation of cellular metabolism.
  • It discusses the role of epigenetic machinery dysfunction in metabolic disorders like diabetes and obesity.
  • The review explores the potential of metabolite manipulation as a therapeutic strategy.

Key Points:

  • Epigenetic regulation is central to cellular metabolism.
  • Dysfunctional epigenetic machinery is linked to metabolic diseases.
  • Metabolites can influence epigenetic processes and disease outcomes.

Conclusions:

  • Understanding the interplay between epigenetics and metabolism is key to addressing metabolic disorders.
  • Targeting epigenetic machinery through metabolite manipulation presents a promising therapeutic avenue.