Cefepime-Associated SIRPIDs in a Patient With Normal Renal Function.
Emily Johnson1, Yousef Hannawi2, Nirma Carballido Martinez1
1Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
The Neurohospitalist
|October 4, 2016
Summary
Cefepime (a common antibiotic) can cause encephalopathy and seizures, even in patients with normal kidney function. Promptly recognizing and stopping cefepime is crucial for treatment, avoiding unnecessary antiepileptic drugs.
Area of Science:
- Neuroscience
- Pharmacology
- Internal Medicine
Background:
- Cefepime, a broad-spectrum cephalosporin antibiotic, is frequently used for serious bacterial infections.
- Neurotoxicity, including encephalopathy and seizures, is a known but often overlooked adverse effect of cefepime, particularly in patients with renal impairment.
Purpose of the Study:
- To report a case of cefepime-associated encephalopathy in a patient with normal renal function.
- To highlight the importance of recognizing cefepime neurotoxicity in a broader patient population.
Main Methods:
- Case report detailing clinical presentation, electroencephalogram (EEG) findings, and treatment response.
- Review of existing literature on cefepime-induced neurotoxicity.
Main Results:
- The patient presented with encephalopathy and stimulus-induced rhythmic activity on EEG.
- Neurological symptoms resolved completely after discontinuation of cefepime.
- Renal function was normal throughout the clinical course.
Conclusions:
- Cefepime-induced neurotoxicity can occur in patients with normal renal function.
- Early recognition and withdrawal of cefepime are key to managing this adverse effect.
- Clinicians should consider cefepime neurotoxicity in patients with unexplained neurological changes, irrespective of renal status.
Keywords:
electroencephalographyelectrophysiologyinfectious disease medicineneurohospitalistneurotoxicityMore Related Videos
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