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![Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62460.jpg&w=3840&q=50)
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Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
Published on: July 1, 2021
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Browning and thermogenic programing of adipose tissue
1Clinical Division of Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Waehringer Guertel 18 - 20, A-1090 Vienna, Austria.
Best Practice & Research. Clinical Endocrinology & Metabolism
|October 5, 2016
Summary
Adipose tissue is a thermogenic organ, not just for fat storage. Browning of white fat depots into heat-producing beige adipocytes offers a promising therapeutic strategy for obesity.
Area of Science:
- Metabolic research
- Adipose tissue biology
- Thermogenesis
Background:
- Adipose tissue's role has expanded beyond fat storage to include endocrine functions via adipokines.
- Recent discoveries highlight adipose tissue's thermogenic capacity through brown and beige adipocytes.
Purpose of the Study:
- To review recent advances in understanding adipose tissue browning.
- To explore the molecular and physiological mechanisms driving thermogenic adipocyte development.
Main Methods:
- Review of current scientific literature on adipose tissue browning.
- Analysis of molecular pathways and physiological stimuli involved in adipocyte thermogenesis.
Main Results:
- Beige adipocytes can develop within white fat depots, demonstrating adipose tissue's plasticity.
- Adipose tissue browning is a key factor in energy expenditure.
Conclusions:
- The thermogenic properties of brown and beige adipocytes present a novel therapeutic avenue for obesity.
- Identifying human thermogenic adipocyte populations and activation pathways is crucial for metabolic research.
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