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Updated: Mar 14, 2026
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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
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Plant phosphates, phytate and pathological calcifications in chronic kidney disease
Juan Manuel Buades Fuster1, Pilar Sanchís Cortés2, Joan Perelló Bestard3
1Nefrología, Hospital Son Llàtzer, Palma de Mallorca, Baleares, España.
Summary
Phytate (myo-inositol hexakisphosphate or InsP6) in foods like legumes and nuts may prevent vascular calcifications and protect bones. Further research is needed to confirm its benefits and risks for dialysis patients.
Area of Science:
- Nutritional Science
- Nephrology
- Cardiovascular Science
Background:
- Chronic kidney disease (CKD) patients face high cardiovascular mortality, partly due to elevated blood phosphorus.
- Vascular calcifications (VCs) significantly increase morbidity and mortality in CKD.
- Dietary phosphorus control is crucial for CKD management.
Purpose of the Study:
- To explore the role of phytate (myo-inositol hexakisphosphate or InsP6) in cardiovascular health, particularly in CKD.
- To investigate the potential benefits and risks of InsP6 in preventing vascular calcifications and other conditions.
Main Methods:
- Review of existing literature on phytate, phosphorus bioavailability, and cardiovascular outcomes.
- Analysis of experimental animal studies and observational human studies concerning InsP6 effects.
- Consideration of InsP6's role in preventing lithiasis, VCs, and osteoporosis.
Main Results:
- Plant-based phosphorus, primarily InsP6, has low bioavailability.
- Restricting phytate-rich foods may limit intake of beneficial nutrients like InsP6 and fiber.
- Animal and human studies suggest InsP6 may prevent lithiasis, VCs, and osteoporosis.
Conclusions:
- Phytate (InsP6) shows potential in preventing vascular calcifications and osteoporosis.
- Further prospective studies are required to determine the benefits and risks of dietary or intravenous InsP6 in hemodialysis patients.
Keywords:
Calcificaciones vascularesCalcifilaxisCalciphylaxisChronic kidney diseaseEnfermedad renal crónicaFitatoHiperfosfatemiaHyperphosphataemiaPhytatePhytic acidVascular calcificationsÁcido fíticoMore Related Videos
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