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RIFM fragrance ingredient safety assessment, ethylene brassylate, CAS Registry Number 105-95-3
Summary
This safety assessment confirms the material is safe for use, showing no genotoxicity or skin sensitization. Comprehensive evaluations support its current application conditions.
Area of Science:
- Toxicology and Chemical Safety Assessment
- Environmental Risk Evaluation
Background:
- The safety of the material under current usage conditions was evaluated.
- A comprehensive toxicological profile was established, encompassing multiple endpoints.
Purpose of the Study:
- To assess the genotoxicity, repeated dose toxicity, and developmental/reproductive toxicity.
- To evaluate local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety.
Main Methods:
- Genotoxicity and skin sensitization were directly tested.
- Read-across approaches using analogous substances were employed for repeated dose toxicity, developmental and reproductive toxicity, and environmental safety assessments.
- Threshold of Toxicological Concern (TTC) was used for local respiratory toxicity, and UV spectra data for phototoxicity/photoallergenicity.
Main Results:
- The material demonstrated no genotoxicity and no skin sensitization potential.
- Margin of Exposure (MOE) values greater than 100 were obtained for repeated dose toxicity and developmental/reproductive toxicity via read-across.
- Local respiratory toxicity was assessed using TTC, and phototoxicity/photoallergenicity was evaluated using UV spectra and existing data.
Conclusions:
- The material is considered safe for use under current conditions based on the comprehensive safety data.
- The evaluated toxicological and environmental endpoints support the existing use of this material.
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