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Deoxyribonucleic acid flow cytometry of benign prostatic disease
A D Deitch1, M A Strand, R W de Vere White
1Department of Urology, University of California School of Medicine, Davis.
The Journal of Urology
|September 1, 1989
Summary
Deoxyribonucleic acid (DNA) flow cytometry of benign prostate cells revealed unexpected aneuploid histograms in some cases. These findings, along with specific cellular proliferation patterns, help distinguish benign conditions from potential prostate cancer.
Area of Science:
- Urology
- Oncology
- Cell Biology
Background:
- Prostate cancer diagnosis often relies on cell analysis.
- Flow cytometry offers a method to analyze cellular DNA content.
Purpose of the Study:
- To evaluate deoxyribonucleic acid (DNA) flow cytometry patterns in benign prostatic aspirates.
- To identify DNA histogram features indicative of benign conditions versus potential malignancy.
Main Methods:
- Performed DNA flow cytometry on prostatic aspirates from 198 patients with benign findings.
- Analyzed histogram characteristics, including DNA index, ploidy, and cell proliferation markers (hyperdiploid and G2 cells).
Main Results:
- 10.6% of samples yielded unsatisfactory histograms.
- Most satisfactory samples (75%) showed expected diploid/near-diploid histograms.
- Unexpected aneuploid histograms (often peridiploid) were observed in remaining samples, typically with low proliferation.
- Inflammatory changes in diploid histograms were characterized by increased hyperdiploid cells without elevated G2 cells.
- 7% of samples exhibited DNA histograms suggestive of prostate cancer, often with high proliferation or non-peridiploid aneuploidy.
Conclusions:
- DNA flow cytometry can reveal benign findings in prostate aspirates, including specific aneuploid patterns and inflammatory changes.
- Certain DNA histogram features, particularly high proliferation in diploid/peridiploid aneuploid samples, are suggestive of prostate cancer.