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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Breathing Better Through Bugs: Asthma and the Microbiome.

Alexander J Adami1, Sonali J Bracken1

  • 1Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT.

The Yale Journal of Biology and Medicine
|October 5, 2016
PubMed
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The human microbiome plays a crucial role in asthma development. Understanding the microbiome-immune system interaction may lead to new asthma therapies and potential cures.

Keywords:
allergyasthmahygiene hypothesisimmune systemimmunitymicrobiomemicrobiota

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Area of Science:

  • Immunology
  • Microbiology
  • Respiratory Medicine

Background:

  • Asthma is a complex respiratory disease with increasing prevalence.
  • It is characterized by airway inflammation and diverse phenotypes.
  • The role of the microbiome in asthma pathophysiology is an emerging area of research.

Purpose of the Study:

  • To review the relationship between the microbiome and the immune system in asthma.
  • To explore how these interactions influence asthma development.
  • To highlight potential therapeutic strategies targeting the microbiome for asthma.

Main Methods:

  • Literature review of recent studies on the microbiome and asthma.
  • Analysis of immunological mechanisms linking the microbiome to asthma.
  • Synthesis of evidence for microbiome-based therapeutic interventions.

Main Results:

  • The microbiome significantly influences immune system development and regulation.
  • Alterations in the microbiome are associated with increased asthma risk and severity.
  • Specific microbial compositions may predispose individuals to or protect against asthma.

Conclusions:

  • The microbiome is a critical factor in asthma development and immune response.
  • Targeting the microbiome offers promising avenues for novel asthma treatments.
  • Further research into microbiome-immune interactions is essential for finding cures.