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Jin Fu Kang Oral Liquid Inhibits Lymphatic Endothelial Cells Formation and Migration
Hai-Lang He1, Dan Wang1, Jie Tang1
1Department of Respiratory Medicine, Affiliated Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210029, China.
Evidence-Based Complementary and Alternative Medicine : Ecam
|October 5, 2016
Summary
Jin Fu Kang (JFK), a Chinese herbal medicine, inhibits lymphangiogenesis, the process of new lymphatic vessel formation. This may offer a new strategy for treating non-small cell lung cancer (NSCLC) by blocking cancer spread.
Area of Science:
- Oncology
- Cell Biology
- Pharmacology
Background:
- Lung cancer is a leading cause of cancer mortality globally.
- Lymphangiogenesis, driven by lymphatic endothelial cell (LEC) formation and migration, is crucial for cancer metastasis.
- Jin Fu Kang (JFK) is an oral Chinese herbal prescription used for non-small cell lung cancer (NSCLC).
Purpose of the Study:
- To investigate the effects of stromal cell-derived factor-1 (SDF-1) and vascular endothelial growth factor-C (VEGF-C) on LECs.
- To determine the combined effect of SDF-1 and VEGF-C on LECs.
- To clarify the inhibitory mechanisms of JFK on LECs and lymphangiogenesis.
Main Methods:
- LECs were differentiated from CD34+/VEGFR-3+ endothelial progenitor cells (EPCs).
- JFK-containing serums were prepared from rats.
- The impact of SDF-1, VEGF-C, and JFK on LEC formation and migration was assessed.
Main Results:
- SDF-1 and VEGF-C promoted LEC differentiation and migration.
- SDF-1 and VEGF-C had an additive effect on LEC formation but not migration.
- JFK significantly inhibited both LEC formation and migration.
Conclusions:
- JFK exerts its anti-NSCLC effects potentially through inhibiting lymphangiogenesis.
- JFK's inhibitory action likely involves the SDF-1/CXCR4 and VEGF-C/VEGFR-3 signaling pathways.
- Natural resources like those in JFK may yield novel anti-lymphangiogenesis agents for cancer therapy.
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