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Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy

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Published on: August 22, 2018

Time resolved diffuse optical spectroscopy with geometrically accurate models for bulk parameter recovery.

James A Guggenheim¹, Ilaria Bargigia², Andrea Farina³

¹PSIBS Doctoral Training Centre, University of Birmingham, Birmingham, UK; Department of Medical Physics and Biomedical Engineering, University College London, London, UK.

Biomedical Optics Express

|October 5, 2016

Summary

This summary is machine-generated.

This study presents a new, efficient method for hyperspectral time-domain diffuse optical spectroscopy, improving accuracy in determining sample optical properties. The approach uses geometry-specific models, overcoming limitations of traditional approximations.

Keywords:

(170.3010) Image reconstruction techniques (170.3660) Light propagation in tissues

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Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

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Published on: October 17, 2016

Area of Science:

Biomedical Optics
Spectroscopy
Optical Physics

Background:

Diffuse optical spectroscopy (DOS) is a non-invasive technique to probe tissue optical properties.
Traditional DOS often relies on analytical approximations (e.g., semi-infinite slab) that can introduce boundary errors.
Accurate optical property determination is crucial for quantitative biomedical applications.

Purpose of the Study:

To introduce a novel, efficient, and accessible approach for hyperspectral time-domain diffuse optical spectroscopy (TD-DOS).
To enhance the accuracy of determining bulk optical properties of samples.
To overcome the limitations of conventional analytical approximations in DOS.

Main Methods:

Development of geometry-specific numerical models for TD-DOS analysis.
Creation of specialized libraries based on these numerical models for bulk parameter recovery.
Comparison of results with the conventional semi-infinite slab approximation.

Main Results:

The novel method demonstrates improved accuracy in deriving spectrally varying optical properties.
Geometry-specific models effectively mitigate boundary effects inherent in analytical approximations.
The approach provides more reliable quantitative optical property measurements.

Conclusions:

The presented TD-DOS method offers a more accurate alternative to conventional techniques.
Geometry-specific numerical modeling is essential for precise optical property assessment.
This advancement facilitates more reliable quantitative analysis in diffuse optical spectroscopy.