Greater variation in affect is associated with lower fasting plasma glucose
Sunjai Gupta1, Robert Anderson2, Richard Ig Holt3
1Institute of Psychiatry, Psychology and Neurology, Kings College, De Crespigny Park, London SE5 8AF, UK.
Heliyon
|October 5, 2016
Summary
Changes in mood are inversely associated with fasting plasma glucose levels. This suggests a complex relationship between affect and glucose metabolism, potentially impacting diabetes risk in individuals with mental health conditions.
Area of Science:
- Psychiatry and Endocrinology
- Metabolic Health Research
Background:
- Mood disorders like depression and bipolar illness are linked to a higher prevalence of diabetes.
- The impact of mood fluctuations on glucose metabolism remains unclear.
Purpose of the Study:
- To investigate the relationship between changes in affect (mood variability) and key glucose metabolism markers.
- Specifically examining fasting plasma glucose and glycated haemoglobin (HbA1c).
Main Methods:
- Utilized data from 379 men and 441 women from the 2003 Health Survey for England.
- Assessed mood variability using the General Health Questionnaire 12 (GHQ12).
- Analyzed fasting plasma glucose and HbA1c levels, employing linear regression to determine relationships.
Main Results:
- A significant inverse relationship was observed between fasting plasma glucose and mood variability score (R² = 0.327, p = 0.02).
- This association persisted after adjusting for sociodemographic factors, anthropometric measurements, lifestyle, and medication use.
- No significant relationship was found between mood variability and glycated haemoglobin (HbA1c).
Conclusions:
- The study reveals an inverse association between affect variability and fasting plasma glucose.
- This finding indicates a more intricate connection between mood and glucose regulation than previously understood.
- Fasting plasma glucose may indicate homeostatic disturbances in certain mental states, influencing diabetes risk and metabolic conditions.
Keywords:
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