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Vascular comorbidities in multiple sclerosis: a nationwide study from Denmark.
Anja Thormann1,2, Melinda Magyari3,4, Nils Koch-Henriksen4,5
1Department of Neurology, Danish Multiple Sclerosis Center, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark. anja.thormann.01@regionh.dk.
Journal of Neurology
|October 5, 2016
Summary
Multiple sclerosis (MS) patients showed fewer vascular issues before diagnosis but a higher risk of cerebrovascular and cardiovascular comorbidities after MS onset. This suggests shared pathways or MS-related complications.
Area of Science:
- Neurology
- Epidemiology
- Cardiology
Background:
- Multiple sclerosis (MS) is a chronic neurological disease.
- Vascular comorbidities are common in the general population.
- The relationship between MS and vascular comorbidities requires further investigation.
Purpose of the Study:
- To investigate the occurrence of vascular comorbidities before and after the clinical onset of multiple sclerosis (MS).
- To compare vascular comorbidity rates in MS patients versus controls.
Main Methods:
- Combined case-control and cohort study design.
- Utilized Danish nationwide registries for individual-level data.
- Matched MS cases with controls by birth year, gender, and municipality.
- Employed logistic and Cox regression for statistical analysis.
Main Results:
- MS cases had decreased cerebrovascular comorbidity before onset (OR 0.69).
- MS cases showed increased cerebrovascular (HR 1.84) and cardiovascular (HR 1.08) comorbidity after onset.
- A numerically decreased, but not statistically significant, cardiovascular comorbidity was observed before MS onset.
Conclusions:
- Lower pre-onset cerebrovascular comorbidity in MS cases may indicate immune protection.
- Increased post-onset vascular comorbidities suggest converging pathways or MS-related complications.
- Further research into a broader spectrum of comorbidities in MS is warranted.
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