Related Experiment Video
Updated: Mar 14, 2026

09:26
Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
Published on: February 6, 2019
22.3K
Alcohol intoxication in non-motorised road trauma
Biswadev Mitra1,2,3, Kate E Charters1,2, John C Spencer1
1Emergency and Trauma Centre, The Alfred Hospital, Melbourne, Victoria, Australia.
Emergency Medicine Australasia : EMA
|October 5, 2016
Summary
Intoxication is common among non-motorized road users involved in crashes, with 15.9% presenting to hospital intoxicated. Routine testing is needed to understand the full impact and improve road safety.
Area of Science:
- Public Health
- Traumatology
- Road Safety Research
Background:
- Non-motorised road users (pedestrians, cyclists) are vulnerable road users.
- Alcohol intoxication is a known risk factor for road traffic crashes.
Purpose of the Study:
- To determine the prevalence of alcohol intoxication among non-motorised road users presenting to a major trauma centre after a crash.
- To identify characteristics of intoxicated non-motorised road users.
Main Methods:
- Retrospective cohort study using data from the Alfred Trauma Registry (July 2009-June 2014).
- Inclusion of non-motorised road users (pedestrians, pedal-cyclists, etc.) involved in road traffic crashes with available blood alcohol concentration (BAC).
- Intoxication defined as BAC ≥0.05 g/100 mL.
Main Results:
- 1323 patients were analyzed; 15.9% were intoxicated (BAC ≥0.05 g/100 mL).
- Pedestrians had a higher intoxication rate (24.7%) compared to pedal cyclists (7.3%).
- Intoxicated patients were younger, more likely male, and presented after hours/holidays.
Conclusions:
- Alcohol intoxication is prevalent among non-motorised road users involved in crashes.
- Current public awareness programs have not reduced the proportion of intoxicated users.
- Routine intoxication testing and penalties for non-motorised road users should be considered to enhance road safety.
Related Concept Videos
CNS Depressants: Alcohol and Nicotine
1.5K
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
1.5K
Depressants
551
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
551
Hypothesis Test for Test of Independence
8.3K
The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
H0: The two variables (factors)...
H0: The two variables (factors)...
8.3K
Drug Toxicity: Risk factors
93
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
93
Drug Toxicity: Overview
117
Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
117

