Related Experiment Video
Updated: Mar 14, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
Published on: August 18, 2022
Pseudomelanosis duodeni: is there a common denominator?
Rosa Coelho1, Armando Ribeiro2, Roberto Silva3
1Gastrenterology, Centro Hospitalar São João, Portugal.
Abstract:
A 76-year-old female patient with a past medical history of diabetes mellitus, stage 3 chronic renal failure and iron deficiency anemia was referred for esophagogastroduodenoscopy (EGD) for evaluation of solid food dysphagia. She had been on oral therapy with ferrous sulfate for several years. Besides a Schatzki's ring the EGD revealed a duodenal mucosa with black-speckled pigmentation. Biopsies were performed and disclosed the deposition of brown (hemosiderin) pigment within macrophages in the lamina propria of normal villi. This endoscopic appearance is called pseudomelanosis duodeni (PD).
Related Concept Videos
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Desmosomes
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
