Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.2K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Photocatalytic Hydrogen Cycling via Benzotrithiophene-Based Mesoporous Covalent Organic Frameworks for Efficient Fine Chemical Coproduction.

Journal of the American Chemical Society·2026
Same author

Identification of TXNIP, FTCD, and HAGH as Key Genes in a Cancer Stem Cell-Driven Prognostic Model for Hepatocellular Carcinoma.

Endocrine, metabolic & immune disorders drug targets·2026
Same author

C1orf226 Promotes Glioma Stemness and Oncogenesis in Glioma via PLK1-Mediated Wnt/β-Catenin Signaling.

Cancer medicine·2026
Same author

Broadband and high-speed terahertz wireless sensing via vertical-transport Dirac-source detector.

Science advances·2026
Same author

Gualou total alkaloids improve lipid metabolism and alleviate atherosclerosis by inhibiting hepatic PLA2G2A-mediated LPC/LPA axis.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

High-Performance Terahertz Photodetectors Based on Spiral Structure-Regulated Graphene.

Sensors (Basel, Switzerland)·2026

Related Experiment Video

Updated: Mar 14, 2026

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
04:00

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Published on: November 15, 2024

939

Hypersplenism: History and current status.

Yunfu Lv1, Wan Yee Lau2, Yejuan Li1

  • 1Department of General Surgery, Hainan Province People's Hospital, Haikou, Hainan 570311, P.R. China; Department of Molecular Biology, Hainan University, Haikou, Hainan 570228, P.R. China.

Experimental and Therapeutic Medicine
|October 6, 2016
PubMed
Summary

Hypersplenism, an enlarged spleen causing blood cell destruction, is classified into primary, secondary, and occult types. Treatment for this condition is individualized, ranging from etiological therapies to surgery.

Keywords:
classificationhistorical reviewhypersplenismpathogenesissplenectomysplenomegaly

More Related Videos

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
08:04

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

17.2K
Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device
04:40

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

Published on: November 4, 2022

1.4K

Related Experiment Videos

Last Updated: Mar 14, 2026

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
04:00

Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension

Published on: November 15, 2024

939
A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
08:04

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

17.2K
Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device
04:40

Bloodless Laparoscopic Partial Splenectomy Assisted by Bipolar Radiofrequency Excision Hemostatic Device

Published on: November 4, 2022

1.4K

Area of Science:

  • Hematology
  • Internal Medicine
  • Pathology

Background:

  • Hypersplenism is a clinical disorder defined by an enlarged spleen (splenomegaly).
  • It leads to the accelerated destruction of peripheral blood cells, causing cytopenias.
  • Understanding its mechanisms is crucial for effective management.

Purpose of the Study:

  • To provide a comprehensive review of hypersplenism.
  • To discuss its historical context, classification, pathogenesis, diagnosis, and treatment.
  • To synthesize current knowledge on managing this condition.

Main Methods:

  • A systematic literature search was conducted.
  • Databases used included PubMed, Web of Knowledge, and CNKI.
  • Relevant articles on hypersplenism were reviewed and findings summarized.

Main Results:

  • Hypersplenism is characterized by splenomegaly and peripheral cytopenias.
  • Classifications include primary, secondary, and occult hypersplenism.
  • Pathogenesis involves splenic retention, phagocytosis, and autoimmunity.

Conclusions:

  • Treatment strategies are diverse, including etiological, non-surgical, splenectomy, and liver transplantation.
  • Management must be tailored to the individual patient's needs.
  • Further research may refine diagnostic and therapeutic approaches.