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Adjunctive aripiprazole in risperidone-induced hyperprolactinaemia: double-blind, randomised, placebo-controlled
G Raghuthaman1, R Venkateswaran2, R Krishnadas3
1, MBBS, DPM, MD, Department of Psychiatry, PSG Institute of Medical Sciences and Research, Coimbatore, India.
Bjpsych Open
|October 6, 2016
Summary
Adjunctive aripiprazole significantly reduced elevated prolactin levels in patients on risperidone, improving sexual dysfunction. This treatment shows potential for managing hyperprolactinemia caused by second-generation antipsychotics.
Area of Science:
- Psychiatry
- Pharmacology
Background:
- Hyperprolactinemia is a common and problematic side effect of antipsychotic medications.
- Second-generation antipsychotics, such as risperidone, are frequently associated with elevated prolactin levels.
Purpose of the Study:
- To investigate the efficacy of adjunctive aripiprazole in managing hyperprolactinemia in patients with schizophrenia maintained on risperidone.
- To assess the impact of aripiprazole on sexual side-effects and psychopathology.
Main Methods:
- A double-blind, placebo-controlled study involving 30 patients on risperidone.
- Aripiprazole (10 mg/day) was administered for 8 weeks, with serum prolactin measured at baseline and endpoint.
- Psychopathology and side-effects were evaluated bi-weekly.
Main Results:
- Adjunctive aripiprazole led to a 58% decrease in prolactin levels, compared to a 22% increase in the placebo group.
- Prolactin normalized in 46% of patients receiving aripiprazole (NNT=2).
- Aripiprazole improved erectile dysfunction in most patients, with no significant changes in psychopathology or other side-effects.
Conclusions:
- Adjunctive aripiprazole is an effective treatment for reducing risperidone-induced hyperprolactinemia.
- This intervention shows promise for managing endocrine and sexual side-effects associated with antipsychotic treatment.
- Aripiprazole did not negatively impact psychopathology or extrapyramidal symptoms.
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