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Serum Amyloid P Component and Systemic Fungal Infection: Does It Protect the Host or Is It a Trojan Horse?

Stephen A Klotz1, Richard E Sobonya2, Peter N Lipke3

  • 1Division of Infectious Diseases.

Open Forum Infectious Diseases
|October 6, 2016
PubMed

Insights

Deep mycoses, or fungal infections, often show a lack of immune response. This study explores the role of serum amyloid P component (SAP) in fungal amyloid interactions and the host

Area of Science:

  • Mycology
  • Immunology
  • Biochemistry

Background:

  • Deep mycoses infections often present with a suppressed inflammatory response, contrary to typical infection patterns.
  • Neutropenia due to chemotherapy is a common but insufficient explanation for this lack of host response.
  • Invasive fungal lesions contain abundant fungal functional amyloid, which interacts with serum amyloid P component (SAP).

Purpose of the Study:

  • To investigate the role of serum amyloid P component (SAP) in the local immune response during invasive fungal infections.
  • To explore the interaction between fungal functional amyloid and SAP in the context of deep mycoses.

Main Methods:

  • Review and discussion of existing literature on deep mycoses, host immune response, fungal amyloid, and SAP.
  • Analysis of the proposed interaction between fungal amyloid, SAP, and the immune system in invasive fungal infections.

Main Results:

  • Fungal functional amyloid is a consistent feature of invasive fungal lesions.
  • Serum amyloid P component (SAP) binds to fungal amyloid.
  • The interaction between fungal amyloid and SAP is postulated to be significant in modulating the local immune response.

Conclusions:

  • The interaction between fungal functional amyloid and serum amyloid P component (SAP) may play a crucial role in the immune response to deep mycoses.
  • Further research is warranted to elucidate the precise mechanisms by which SAP influences the host's response to invasive fungal infections.
Keywords:
amyloidcandidiasisfunctional amyloidfungiserum amyloid P component

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