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Tissue Engineering of the Intestine in a Murine Model
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Intestinal Failure in Children.

Theodoric Wong1, Girish Gupte2

  • 1Department of Gastroenterology and Nutrition, Birmingham Children's Hospital, Birmingham, UK.

Indian Journal of Pediatrics
|October 6, 2016
PubMed
Summary
This summary is machine-generated.

Survival rates for children with intestinal failure, especially extreme short bowel syndrome, have improved due to better management and intestinal transplantation. Parenteral nutrition is key for patient survival.

Keywords:
Faltering growthGrowthIntestinal failureIntestinal transplantationParenteral nutritionSTEP procedureTotal parenteral nutrition

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Area of Science:

  • Pediatric Gastroenterology
  • Surgical Innovation
  • Transplant Medicine

Background:

  • Improved survival in pediatric intestinal failure over the last 10-15 years.
  • Advancements attributed to better pathophysiology understanding, line care, team approach, and intestinal transplantation.
  • Parenteral nutrition remains essential for patient survival.

Purpose of the Study:

  • To review contemporary approaches to managing pediatric intestinal failure.
  • To cover surgical, dietary, and medical management strategies.
  • To discuss home parenteral nutrition and intestinal transplantation advancements.

Main Methods:

  • Literature review of recent advancements in pediatric intestinal failure management.
  • Synthesis of information on surgical techniques, nutritional support, and transplantation.
  • Analysis of contemporary treatment strategies and outcomes.

Main Results:

  • Enhanced survival rates in children with intestinal failure, particularly short bowel syndrome.
  • Intestinal transplantation is a recognized viable option for select patients.
  • Multidisciplinary care and optimized parenteral nutrition are critical.

Conclusions:

  • Contemporary management strategies have significantly improved outcomes for pediatric intestinal failure.
  • A comprehensive approach integrating surgery, nutrition, and transplantation is vital.
  • Continued research and innovation are crucial for further advancements.