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Published on: August 22, 2014
Nanohybride Materials Based on Magnetite-Gold Nanoparticles for Diagnostics of Prostate Cancer: Synthesis and In
A E Machulkin1,2, A S Garanina3, O A Zhironkina4
1Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia. alekseymachulkin@rambler.ru.
Abstract:
We synthesized a fluorescence conjugate and modified magnetite-gold nanoparticles carrying prostate specific membrane antigen (PSMA) as the ligand. Analysis of their binding to human prostate cancer cell lines PC-3 (PSMA-) and LNCaP (PSMA+) showed selective interaction of the synthesized conjugate and modified nanoparticles with LNCaP cells. These findings suggest that these nanoparticles can be used in tissue-specific magnetic-resonance imaging.
